Coulson is more determined than ever to get to Gideon Malick and put to an end to Hydra once and for all in the aftermath of his trip to Maveth. Meanwhile, Daisy and the team encounter more Inhumans who have powers like they've never seen before, but will they be friends or enemies of S.H.I.E.L.D?
Agent Daisy Johnson must call upon the Secret Warriors for an inaugural mission that will leave no member unscathed, and S.H.I.E.L.D. learns more about Hive's powers, forcing them to question everyone they trust.
The S.H.I.E.L.D. team is left reeling and decimated as Hive continues to sway Inhumans to his side. But there is a sliver of hope as Agents Fitz and Simmons follow a lead that may be able to stop the maniacal Inhuman once and for all.
In the aftermath of the events of Captain America: Civil War (2016), S.H.I.E.L.D feels pressure to reveal their involvement with Inhumans. But with the stakes higher than ever and Hive growing stronger, the team is tested in ways they could never anticipate.
Daisy has left S.H.I.E.L.D. and is trying to solve the mystery of a bunch of serial killings in the Los Angeles area. At the same time her old friends suspect her for the killings and are following her trail in an attempt to find her.
Coulson, Mack and Fitz try to locate and neutralize a rogue group looking to stop Inhuman registration worldwide; Simmons and Dr. Radcliffe have only a short time to save May before she succumbs to her illness.
As Ghost Rider's quest for vengeance brings him into an explosive confrontation with S.H.I.E.L.D., Coulson and Mack must rely on an unlikely ally in their time of desperate need; and Daisy reunites with a familiar face to stop the Watchdogs.