After being arrested for the attempted assassination of the POTUS Sam and Dean must find a way out of a government detention facility in the middle of nowhere. Determined to find her sons, Mary and Castiel seek help from an unlikely source.
Sam and Dean investigate an attack by an invisible hellhound at a campsite. Meanwhile, two of Crowley's own personal demons uncover what he has been hiding. Elsewhere, Castiel gets a lead on Kelly Kline.
Dean and Sam let Mick Davies tag along on a case as they search for a werewolf and they run into Claire Novak, the reunion is short lived after Claire is bitten and the brothers race to find a way to help her before she turns.
Alicia Banes calls Mary for help after her mother, Tasha goes missing. Sam answers Mary's phone and he and Dean head out to help Alicia and her twin brother, Max find their mother who was hunting a powerful witch. Meanwhile Mary starts to have some doubts about the British Men of Letters.
Sam and Dean are alarmed when they learn hunters are being killed by suspicious "accidents" all over the country. They decide it is best to find Mary and make sure she's safe. Meanwhile, Toni is back in the states and she and Mary face off.
A wraith kills her friend and Missouri enlists the help of Dean and Jody to protect her granddaughter, Patience, and could be next on the wraith's hit list. Sam continues to work with Jack to control his powers.
When multiple patients of grief counselor Mia Vallens turn up dead, Dean, Sam and Jack investigate the mystery surrounding the murders and, each inadvertently, are forced to deal with unresolved grief of their own.
Castiel is reunited with Jack and together with Sam and Dean, they head to a sleepy old western town to investigate a murder. Dean gets to live out his boyhood fantasy when he comes face to face with a famous, gun-slinging outlaw.
Jack, desperate to prove to Sam and Dean that he is good and that he can control his powers, enlists the help of a dream walker named Kaia to help him find Mary Winchester and save her from the alternate universe. However, when plans go awry, the Winchester brothers are the ones who need saving.