Advanced metalworking is shown throughout the film from jewelry to swords (which were not made from metal until 3,000BC , 7,000 years after the setting of the film) that simply did not exist in 10,000 BC.
The earliest Egyptian pyramid was erected circa 2630 BC. The film doesn't show the Giza pyramids as completed, which may be an effort to satisfy both those who believe the Giza pyramids are relatively recent, and those who believe they are substantially older.
The Nile River is shown in the pyramid scene; however it is too narrow to be realistic. The average width of the river is 1.75 miles with the narrowest point (roughly the same distance shown in the film) located in a gorge near where the Aswan dam now stands, hundreds of miles upstream from where the film is set.
The little ice age as depicted in the film is how it would have been in Europe and certainly not in north Africa. Beyond this, northern Africa, including the Sahara across to the Red Sea was just as hot and dry as it is today. The geography in the film makes no sense whatsoever.
Several scenes show mammoths galloping. Mammoths were closely related to modern elephants, and couldn't gallop because of their physiology. At best, they could move at a fast trot, like elephants do. They were also never domesticated as pack animals.
One of the features of the Nile river is that it flows to the north while the prevailing winds blow towards the south. This made travel along the Nile quite easy. In the film a boat is shown sailing northward on the Nile with its sails up, which would have fought against the wind. In reality, they would not have used a sail but floated with the current.
While slaves may have been involved in the peripheral tasks involving the construction of the Pyramids at Giza, there is no evidence that they were the primary laborers on the project. In fact graffiti found in and around the pyramids make it clear that skilled craftsmen and paid laborers were the primary builders of the edifices. A town-like location has been uncovered near the pyramids containing a large number of dressed stone houses which housed the laborers, with contents that showed that they earned wages and had possessions that varied from one house to another.
In several shots, the stars in the night sky show modern constellations. Due to astronomical movement, the constellations were slightly different 10,000 years ago but not enough to make much of a difference. The distortion of Orion, however, was greatly exaggerated.