(at around 39 mins) Cris (Nicolas Cage) tells a joke about a "Zen master" ordering a hot dog. Cage says, "he said he'd have 'one with everything.'" The punch line should be "make me one with everything." Cage's wording misses the point, and the expression on Liz (Jessica Biel)'s face suggests she misses the point too.
After leaving Havasupai, they encounter a rainstorm heavy enough to flood the road, so they turn back about 2 miles. The following morning, during the run down the mountainside, the ground is dry and dusty.
(at around 2 mins) At the beginning of the film, Johnson was sitting in a diner and checked his watch on his left wrist. A moment later, when he raised his right hand to wipe sweat on his forehead, there was another watch on his right wrist.
(at around 43 mins) After Cris produces a rose for Liz in the motel room, she is holding it in her right hand. When she embraces him, the rose is behind his back. When the scene cuts to closeup, her hand with the rose in it is up near Cris' face.
(at around 1h 8 mins) When Johnson is running out of the FBI building, the helicopter spots him and shows him running down the middle of the road against traffic, but as he comes to a stop at the intersection, he is still in the middle of the road, but running with traffic.
(at around 17 mins) When Johnson foresees the conversation with the FBI agent in his garage, the conversation lasts three minutes. Since the conversation never really happens, and he can only see two minutes into the future, it wouldn't have worked.
During the scene when Chris and the agents are walking along the catwalk, just prior to Chris's precognition of getting shot by a sniper from behind them: As Chris and the FBI agents are about to turn 90 degrees left on the catwalk, there is a cylindrical duct of some kind behind them with a white tarp covering the end. As they walk past it, the tarp gets sucked down and pulled out of sight - possibly a film crew action, or just part of what the machinery is being portrayed to do. However, after his precognition of getting shot, the scene rewinds to their approach on the catwalk, but this time, the white tarp at the end of the tubing does not get sucked in, it remains covering the end of the duct.
Agent Callie Ferris' hair lightens and darkens as the movie progresses. The stand-in's hair is darker. The back appears dark red nearly black in some scenes. Also, in some scenes at the beginning her hair appears dark almost black.
(at around 1h 26 mins) When Cris wakes up in bed with Liz at the end of the movie, there is no sunlight on Liz's hair from the shot looking down on the bed but when it switches angles, there is sunlight in her hair.
(at around 37 mins) When the van driven by Cris pulls up to barrier at washed out road, Cris is driving and Liz is the passenger. In the next scene when the special agent reviews the video of the van, Liz is driving and Cris is the passenger.
(at around 53 mins) When Cris steps outside to drink the orange juice, the sniper is looking straight ahead (horizontally) then in a later shot the sniper is looking upwards. The view (through the telescopic lens) appears to be downwards (the top of the veranda rails can be seen).
(at around 1h 19 mins) During the outdoor firefight at the dock, two cuts before the cut that shows the bad guys reaching the top of the ladder to the ship, three FBI agents in the foreground are seen shooting one bad guy amid some cargo containers. In the background on the right side of the frame, a strangely nonchalant terrorist is standing against a dark container, gun casually pointing straight up, watching the carnage.
(at around 32 mins) The characters visit the Indian village of Supai, Arizona, and two of the associated waterfalls, Havasu and Mooney. In the film it appears that they park their car and walk to these locations in regular street clothes and very quickly. In actuality the village of Supai is 8 miles (through the desert) from the parking lot. Havasu falls is another 2 miles beyond that and Mooney falls is 2 more miles plus a nearly straight vertical climb of 150-200 feet to the bottom. Accomplishing this trip, at the very least, would require carrying a water supply and wearing appropriate boots and clothing.
(at around 18 mins) When Agent Ferris explains Frank Cadillac's predicament (stolen vehicle, attempted armed robbery) she tells him he could end up in Folsom State Prison. Folsom is a California prison, the crimes were committed in Nevada.
(at around 5 mins) Early in the film Johnson walks into a casino off of Fremont street in the heart of Las Vegas. (at around 9 mins) Upon exiting the casino later, however, he finds himself just off the Las Vegas Strip across from Paris Hotel and Casino approximately 2 ½ miles away from Fremont street.
(at around 1h 8 mins) After Cris escapes custody from the FBI in downtown Los Angeles, the helicopter surveillance, while reporting his escape route, states that he's headed south on Fifth, then east on Broadway. In downtown Los Angeles, Fifth Street runs east-west, while Broadway runs north-south.
(at around 20 mins) Early scene in which Mr. Roybal head of security is met by the two "Nevada Gaming commission officers" this takes place on the roof of a parking structure in which the camera view shows the Stratosphere tower over the left shoulder of the agent and another casino with lights on the roof over his right. There is no such parking structure and as such the Stratosphere tower and casino are completely by themselves on the strip with a good long walk to the Sands being the closest casino and even its 3 or so blocks away.
(at around 1h 4 mins) When Cris is watching television to determine the time and place of the explosion, a news anchor describes a hurricane in the Atlantic as an "F-3" storm. The Fujita Scale is used to rate the intensity of tornadoes. Hurricanes are classified using the Saffir-Simpson scale. A hurricane of that strength would properly be called a Category 3 storm.
(at around 1h 11 mins) The sniper twice tries to make a cell phone call. Both times he gets three tones and a recorded message telling him, "Your call cannot be completed as dialed. Check the number and dial again." Between attempts his phone's LCD reports "NO SERVICE" because previously all cell service was shut down. Such recordings can only come from the service; they're not embedded in every handset.
(at around 33 mins) The head to Havasupai is a dirt area the size of a football field with only a few hitching posts and a helicopter pad. There are not any buildings that look like the one portrayed in the movie.
(at around 36 mins) When Callie has a visitor at the indoor firing range, the range master is heard announcing a cease-fire for the entire range and then Callie removes her ear protection. She then proceeds to fire several shots in an act of bravado without ear protection for her guest and her, and in gross violation of the range orders meant to protect other shooters.
In most of the world, potassium iodide (used to combat radiation poisoning) is sold in blister packs, not prescription bottles. This is because it is meant for long-term storage and because the pills are fragile and would be easily crushed if stored in a pill bottle. The terrorists would have had such blister packs and not bottles.
One of the French terrorists has a rifle to make a very long range shot. However, it is equipped with a silencer, which anyone who is familiar with rifles knows a silencer can, and typically will dramatically alter the accuracy of a long range shot. A real sniper or sharpshooter would never risk this; especially such an important shot.
(at around 32 mins) As Chris and Liz arrive at the Indian village, Liz announces it is the "Havasupai Reservation". The movie makes no further effort to specifically define where or what the location is. Since the Havasupai Reservation consists of 189,000 acres (approximately 295 sq miles) and has several waterfalls throughout, the audience is led to believe that it is a nondescript, perhaps even fictitious location. Since the movie makes no specific identification of this location, other than the Havasupai Reservation, any claims made regarding errors in geography (the village of Supai, the trail head to Havasupai and/or Havasu Falls among others) are unfounded.
The FBI is able to quickly shutdown all cell signals once they determine where Liz will be left with the explosive vest so the sniper can not call in the kill. They then determine that the vest is wired to receive a cell signal to detonate. Can't they simply disable the cell signal again to not allow her vest to receive the detonation signal?
They were able to determine the killer in the motel room across the street was part of the terrorist group because they found a bottle of pills for radiation poisoning. This was after the FBI agent stated that the room had been professionally wiped down of fingerprints and other evidence. The terrorists immaculately wiped down the room but left a dead body and a prescription pill case?
In a diner scene we meet Jessica Biel for the first time. She is wearing a pair of pearl stud earrings. She leaves the diner, gets into a car and suddenly she's wearing small turquoise earrings. When she reaches her destination, what do you know? She is suddenly wearing her pearl stud earrings again.
(at around 5 mins) The Golden Nugget on Freemont Street is clearly standing in for the fictional Mystique Casino in the film. When Cris enters the casino, the large 'G' and 'N' are visible on the doors and a plaque with the Golden Nugget logo can be seen on the wall.
The "wind" that blows off hats and causes clothing to flap when they are on the deck of the ship in the harbor during the foretold atomic blast would actually have been an overpressure wave generated by the bomb's detonation. The characters shown on the ship would have thrown backwards dozens of feet or simply splattered well before the ship overturned.
Near the end, the FBI team kills "Mr. Smith" (Thomas Kretchmann), the terrorist holding "Liz" (Jessica Beal). They could have easily wounded him instead, giving them ample opportunity to interrogate the terrorist. With 8 million lives at stake, I'm sure our government would have used "any means necessary" to find out everything he knew. This is a huge hole in the plot; it could have been done at other opportunities as well.
About 11 minutes in, Cris is being chased by Las Vegas Police cars. He is driving a Dodge Charger he just stole. The first time he crosses the train tracks, his car is demolished by the train that was coming. The next time (a moment later) he beats the train by speeding up earlier. The first time, there were only 3 or 4 cars being pulled by the locomotive; however the second time, the train is much longer; at least double the number of railroad cars.