(at around 1 min) In the opening sequence Kimberly's car keys are shown. Her key chain is an evil eye bead. The evil eye, in middle eastern cultures is a talisman that wards off evil spirits and negative energy, and by doing so protects the owner. There are also other superstitions regarding the evil eye, the main one states that the evil eye can not be bought for oneself, it has to be gifted to them.
In the original Final Destination (2000), many characters are named after black-and-white horror film stars or directors. In this film, Kimberly Corman is named after famous horror director Roger Corman.
(at around 31 mins) Filmmakers say that the man hanging on the jail bars when Kimberly walks into the insane asylum is put there to pay homage to Chief Bromden (Will Sampson) in One Flew Over the Cuckoo's Nest (1975).
This is the only disaster to have no memorial services for the casualties. This disaster has the exception of being the only one in which the death order was reversed, since Death did it to start its list anew, due to a remaining survivor of Flight 180 still being alive.
(at around 1h 9 mins) The TV news van at the farm has the call letters WWED which is registered to a classical music station in Virginia meaning the crew picked those letters on purpose. They stand for "When Will Everyone Die."
(at around 32 mins) When Kimberly enters the sanitarium the words "Get them off me" can be heard coming from one of the cells. This is a reference to a lunatic (also imprisoned in an asylum) in Hellbound: Hellraiser II (1988), who carves himself up with a straight-razor because he suffers from a delusion that he is covered with bugs.
(at around 15 mins) When Officer Thomas Burke sees the pileup, he runs to his car and radios in, "This is Unit 13, requesting medical assistance and back-up for a major traffic accident." The number 13 is considered unlucky.
The trivia items below may give away important plot points.
(at around 27 mins) Originally, Devon Sawa was to reprise his role of Alex Browning in this film, but a dispute concerning his contract with New Line Cinema could not be settled. In this film, it is implied by a newspaper clipping that his character, Alex, was killed off by a falling brick to the head.
(at around 22 mins) When Evan is in his kitchen before his death, he leans over to get something out of his fridge and you can see the letter magnets "HEY E" on the side of the fridge. When Evan puts the leftover Chinese food container on the counter, the "H" magnet falls off and lands in the container. The letters left spell out the word "EYE," which foreshadows that Evan will die when he is impaled through the eye with a fire escape ladder.
(at around 23 mins) When Evan is examining his new ring, the horseshoe shape is pointing downwards, which is considered bad luck. It is immediately after this that the chain of events begin that lead towards his death.
(at around 29 mins) When Nora tucks Tim in at night, dimming the lights, his face is illuminated with a skull outline, and can be better seen when the scene dissolves into the next, foreshadowing his death.
(at around 47 mins) William Bludworth, the mortician, says that only new life can break death's cycle, a life that wasn't meant to be. This is already proven false as Alex was technically dead after he was electrocuted in the first film yet he and Clear still die.
Clear is partially responsible for Nora's death. Eugene and Nora were riding the elevator to the L level to leave Officer Burke's apartment, which is on the third floor. After seeing the sign of a man with hooks, Clear runs to the elevator, pressing the down button, but then decides to take the stairs. It was because of this that the elevator, after stopping at the L level, ascended upwards to reach the third floor where Clear pressed the elevator button, and ultimately severing Nora's head (Eugene tried pressing the elevator buttons in the elevator itself, but Death broke it).
The fridge magnets on Evan's refrigerator spell "HEY E".The H falls, leaving the word EYE. The H that fell also looks like part of a ladder, foreshadowing the fire escape ladder that would fall on Evan's eye.
Prior to his death, Rory asks Kimberly if it will hurt when he dies. Unsure of the answer, she says "I don't know". He later dies in an excruciating manner (his body is trisected by a barbed wire fence).