The show did well, attracting many viewers during its initial run, but Warner Brothers tried to sell commercial slots on this show, on the basis that kids were its main audience. However, it soon turned out that most regular viewers were fourteen years or older. It was considered to move the show to primetime, but in the end, it was cancelled after twenty-four episodes.
Paul Rugg, who had originally been hired as a writer for the show, was brought in to demonstrate what he thought Freakazoid should sound like when a suitable voice actor couldn't be found. The recording of his interpretation was submitted to Executive Producer Steven Spielberg for approval, and Rugg ended up being cast in the title role.
In season one, episode two, "Doomsday Bet", Toby Danger and Dr. Vernon Danger were played by Scott Menville and Don Messick, respectively. The characters were spoofs of Jonny Quest and Dr. Benton Quest from Jonny Quest (1964), who were also respectively voiced by Menville and Messick.
In season two, episode two, "The Freakazoid," Freakazoid gets into an argument with Wakko Warner (from Animaniacs (1993)) and the Brain (from Pinky and the Brain (1995)) about which of their shows is the favorite of Steven Spielberg. During this argument, Freakazoid claims that he is Steven's favorite, because he got a memo. This joke is based on a real memo that Paul Rugg (Writer and voice of Freakazoid) recieved from Spielberg while working as a writer on Animaniacs (1993).
The bug, that Dexter's computer exhibits, is a parody of the FDIV bug that plagued the first run of the Intel Pentium CPUs in the early 1990s, which made headlines when technical users complained about it (and eventually got their CPUs replaced under warranty).
The sequence of keystrokes that triggered the bug in the Pinnacle chip, responsible for turning Dexter Douglas into Freakazoid, is "@[=g3,8d]\&fbb=-q]/hk%fg", followed by DELETE. Also, on Dexter's keyboard, DELETE is in BACKSPACE's usual position, and marked in a slanted lower-case font, which is typical of an Apple Computer keyboard for a later Apple II or a Macintosh.
The theme song includes a reference to the Andy Griffith Show with the line "Floyd the Barber cuts his hair" Floyd the Barber is a character on the show, and the animated opening show's an animated version of Floyd Lawson.
In nearly every episode, an odd-looking character called Emmitt Nervend makes small cameo appearances. The character was based on a sketch by producer Mitch Schauer. Tom Ruegger saw the sketch and asked Schauer if he could use it in the show.