The Facts of Life (1979–1988)
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All four characters were phased out when the show was re-tooled starting with Season 2 (when Jo made her debut). Molly's final appearance was in Episode 2.2 ("The New Girl: Part 2").
Nancy, Sue Ann, and Cindy made occasional appearances through Season 3, and all three returned in Episode 8.6 ("The Little Chill"). Molly was mentioned in that episode, but did not appear (aside from flashback scenes, possibly due to actress Molly Ringwald's film schedule). Edit
The series ends over a span of several episodes that wrap up the storylines of each of the girls:
In Episode 9.19 ("Till Marriage Do Us Part"), Jo marries Rick, and Blair breaks up with Casey.
In Episode 9.22 ("Big Apple Blues"), Natalie moves to an apartment in Soho.
In Episodes 9.23 and 9.24 ("The Beginning of the End," "The Beginning of the Beginning"), Blair learns that Eastland is losing money, so she buys the school, becomes the new headmistress, and allows boys to enroll. Tootie is accepted to drama school in New York. Edit