Quincy aggressively goes against a young colleague who's trying to prove an acquaintance of his is guilty of murdering his infant son. The infant was afflicted with, a degenerative, and ofttimes, fatal illness. Quincy's convinced of his friends' innocence, but it'll be tough to prove.
Quincy must unravel the mystery of who murdered the town bully in a small community outside of Los Angeles. He runs into opposition as it seems that everyone in town wants to protect the killer, including local law enforcement.
When a cancer patient who's undergoing a new treatment leaves the hospital and dies, it's thought she succumbed to the cancer. But when some people whom she came into contact with also die, it's believed the treatment mutated into a virulent disease. The doctor who created the treatment's told by his boss he's brunt let go immediately. He finds work with a pharmaceutical company only interested in the bottom line. When yet another person becomes ill, Quincy implores the besieged doctor to try and develop a cure.
Michael Morishima, a good friend of Sam's, is murdered in the Little Tokyo section of Los Angeles. It turns out that he was investigating possible Yakuza activity in Los Angeles. Unfortunately, Michael's old fashioned father now wants revenge. Now Sam and Quince must find the old man before he becomes a victim himself.
A narcissistic psychopath kidnaps the granddaughter of a former Congressman. He says it will be "Divine Retribution" if she dies, and the fault for her death will rest upon the shoulders of the Congressman and Quincy.
When a young man who dies in an industrial accident because he couldn't read the hazard signs. Quincy takes on the problem of adult illiteracy. A problem that hits close to home with Quincy, when he finds that his friend can't read.
A substandard foster home is responsible for the death of a 7 year-old boy. Quincy and Emily, try to start a new program, so that his older brother can be reunited with his troubled family, where a new stable environment be created.
An elderly woman is robbed and murdered in her apartment. Next target, Quincy. Sam takes trace evidence at the lab before Quince goes to hospital, so that Monahan can track the vicious killers. Quincy struggles with anger from the mugging.
A formerly famous theatre star dies at the end of a robber's gun. Her sister (Rosemary DeCamp), Quincy, and Monahan look for the killer. Her agent, Morris Pearmutter, looks for a comeback in the circumstances.
A dock worker is seriously injured in an accident and loses his arm in the process. He is taken to an experimental hospital called Project Hope headed by a dedicated surgeon named Gabriel McCracken where his arm is reattached. The operation is a success, but a complication arises and he loses the use of his good arm. Now McCracken and his staff of cutting edge surgeons try to find a way to help the young man lead a better quality of life.