Perry compiled dozens of feature, television, and stage credits during a long career that began when he was discovered by Lucille Ball, who put the young actor under contract to Desilu Studios. He co-starred with Pat O'Brien in the 1960 ABC series Harrigan and Son, and co-starred with Chuck Connors and Ben Gazzara in the 90-minute drama Arrest & Trial.
Perry was a guest star on the Star Trek TV series in a memorable first-season episode in 1967, “Tomorrow Is Yesterday,” playing Captain John Christopher. He appeared on Love, American Style, Ironside, The F.B.I., Hawaii Five-0, Barnaby Jones, The Bob Newhart Show, Quincy, CHiPs, The Fall Guy, and many more. He also recurred on programs such as The Facts of Life (as Charles Parker) and Falcon Crest (as John Costello from 1982-