An egocentric actor has a series of "accidents" causing the nervous producer of the show the actor is in to hire Rex to solve who is trying to off the pompous actor. Lots of suspects, but thanks to a poisoned canteen the killer is found.
Jeff recounts how he took in struggling nerd Stu as junior partner, after Jeff rescued a beauty from a kidnapping plus nabbed a car ring single-handed, after bow-tied, all-thumbs Stu botched the car theft investigation. Jeff's princely version of the origin of 77 Sunset Strip is in response to Rex making a rash mistake by asking Jeff how their agency started. As a true detective, Rex needs all the facts to close a case, so he grills Stu for his version of the events.
Jeff is hired by Maritza, a much married socialite to steal her jewels in an insurance scam. When he turns her down she frames him for theft. But it's her missing love letters that have several Hollywood lotharios on edge.
Jeff enters the world of espionage when he is asked to impersonate a brilliant scientist. He must keep up the subterfuge as he tries to ferret out who might be passing on intelligence to the nation's enemies.
Baxter Kellogg, a former star, is attempting a comeback but loses his luck charm at a party. Stu is hired to locate it but finds instead a secretive wife, a resentful nephew, an unemployed starlet plus a blackmailer who meets misfortune.
Jeff is asked by Lt. Gilmore to look into the disappearance of $85,000 hidden by gambler Stanley, recently out of prison. Jeff gets nowhere as his fiance Francine and friends claim ignorance. But a murder changes the investigation's course.
Rex heads to an old mining town, hired by the local boss Henning. After he turns down the job he's prevented from leaving. He becomes involved with Notch who holds the deed to a valuable claim that several of the locals want their hands on.
Stu is hired to find a missing husband, David Todd a once well known pianist who left the spotlight. Stu finds him playing at out of the way club where David insists his wife wants him back to murder him. Events unfold that the investigator must untangle.
Lt. Gilmore enlists Jeff when he's perplexed by a series of unrelated murders. Spencer's work reveals all had a connection to boats plus spoke French. Jeff enlists Suzanne's help but an encounter with a surly marina owner puts her at risk.
Meek bookkeeper Wilmer Zaleski picks 6 of 8 winners every day at the track, attracting the attention of hoods Flip & Schoolboy plus a statuesque billionaire track dilettante. Babs hires Stu to find out Zaleski's secret, while the strong-arms pummel Wilmer and kidnap his daughter. Maverick's a sure bet to win, but Roscoe has to pull an all-nighter to pick the other 5, to draw the kidnappers out in the open.
Jeff is hired by Fay Dakota to protect her estranged husband Flint on the set of his comeback western. A series of mishaps have plagued the film plus Flint's interest in starlet Rhonda creates complications as Jeff and Roscoe work as extras.
When Stu's pilot friend Hal is fired for reporting a dead body that disappears Stu decides to help. An vehicle search reveals the involvement of advice columnist Amanda Strong and her gigolo husband Bowman that raises suspicions.
Jeff is hired by a high end swimwear company to discover why their new designs appear first at their primary competition. Jeff places Suzanne as a model at the firm that unravels a complicated series of deceptions.
While Bailey and Spencer are out, Randolph takes an assignment from a mysterious South American girl, but he's apparently killed en route to her country when his plane explodes. The other detectives suspect he was actually kidnapped.
Randolph awakens from a drugged state to find he has been kidnapped by a banana republic's crooked politicos, and forced to impersonate a dead leader the people trust. Bailey and Spencer enlist Kookie and Roscoe to help in a rescue mission.
Rex is engaged by Gunnar Isis, a ruthless international tycoon, to guard a priceless diamond tiara. When it is stolen from his mistress, lovely ballerina Amanda Sant, Rex is thrown into a maze of murderers, blackmailers and Nazis.
Suzanne goes undercover at females-only El Rancho Aphrodite when a actor dies suspiciously and a boozy actress is suspected of being involved. A studio hires Bailey & Spencer to help the bombshell make it through rehab , but someone sabotages her riding saddle and plants hooch in her drawer. Spa goers include a gossip columnist, a rival starlet, and others connected with the dead actor, such as a Waco riding instructor.
An overly functional family spins Jeff's head like a Lazy Susan, over a murder/jewel heist where nothing makes sense. A precocious grandchild with a pet ocelot bedevils Roscoe, one daughter's missing, and sister Lally's draped all over Jeff. Narcotics, somnambulism, an asylum visit, an elusive psychiatrist, and a mother who makes as much sense as Gracie Allen challenge the Bailey & Spencer firm's patience and resources, as everyone feeds Lt. Gilmore straight lines.
Stuart investigates the case of a cat burglar who wears costumes from old films. He suspects Roland Dumont, an unemployed actor who has not made a film in 20 years, and rents Dumont's estate to get close to the suspect.
An army buddy of Stu's asks him to be responsible for delinquent Speed Minton. Stu and his friends make progress straightening out the troubled youth but his ex-con brother Nate shows up and tries to draw him back into a criminal life.
A popular musician Gandy Waters is believed to be the target when a member of his band is murdered. Jeff goes on the road to protect Gandy plus find the killer. He stumbles onto a case of blackmail and a very unhappy wife.
This is a one-man show as Efrem Zimbalist Jr. does a solo performance. Stu Bailey is lured to a desert hide away where an old enemy lies in wait to kill him. Only the enemy's voice is heard and never seen.
Jeff is asked by old naval buddy Captain Ivers to do undercover work at a nearby military base. He brings in Suzanne, Roscoe and Kookie as a yeoman to help protect a top secret computer project. Kookie helps out a lovelorn Harold.
Santa is killed in the holiday parade on a float with an aging actress. Then the actress is shot at during the Tournament of Roses parade. Jeff is hired to protect her. There are not many suspects, but more incidents. The police are looking foolish. Great cast including Marilyn Maxwell, Yvonne Craig, and Victor Buono.
Stu is hired by Montaigne, uncle and guardian to Drake, a wealthy youngster interested in drag racing. Threats have been made against Drake's life unless $100,000 is paid. Stu uses JR and Kookie's car expertise in solving the case.