Sam and Dean Winchester were trained by their father to hunt the creatures of the supernatural. Now, their father has mysteriously disappeared while hunting the demon that killed their mother, 22 years ago.
A friend of John's calls Sam and Dean for help about a strange recording on the black box of a crashed plane. They soon realize that the demon which caused the crash is picking off the crash's only seven survivors.
Sam and Dean investigate an age-old urban legend known only as the Hook-Man, the spirit of a 19th century pastor with a twisted sense of morals that is unknowingly being used as an innocent girl's attack dog.
Following visionary Sam's recent nightmare about the former Winchester home in Lawrence, Kansas, where the present dwellers, Jenny from Wichita and mother to two small kids, are suspiciously accident-prone, Dean reluctantly accepts to drive there. Dean and Sam reassure Jenny but follow up on the kids fear of a flaming creature in the closet. They consult Missouri Moseley, their father John's old medium friend, and together with the spirit of Mary Winchester, confront an evil poltergeist, but a second ghost intervenes and someone hides behind Missouri.
While investigating a haunting in an abandoned asylum and rescuing two teenagers who ventured in, Sam and Dean become trapped with the spirits of those who had died in a riot decades ago, one of which was a doctor who causes extreme rage in his victims.
After Dean is fatally injured on a case, Sam thinks he's found a cure in a preacher who performs miracles. However, after they discover that these miracles are not as 'holy' as advertised, the brothers race to stop them before another innocent life is sacrificed.
When Sam's visions start happening while he's awake, he and Dean investigate the unusual murders he foretold only to find them all to be true. And that perhaps he's not the only one with special abilities.When visiting the Millers the boys go as priests.
While looking into a mysterious murder in Illinois, Sam and Dean come across Meg, an old 'friend' of Sam's, who may be far worse than they ever thought possible and who plans to use the brothers as bait to trap their father, John.
Dean gets a second chance to right a wrong from his past when the brothers get a mysterious tip from their father about a case they'd worked years ago, but left unfinished after Sam was nearly killed by the creature.
When two sets of owners of the same painting are brutally murdered, Sam and Dean investigate with the help of an auction house owner's daughter, all while Dean shamelessly tries to pair her with his little brother.
After Daniel Elkins, a vampire hunter and John's mentor, is murdered, Sam and Dean are surprised when John himself shows up to solve the case. John discovers the vampires have taken an antique gun, which has the power to kill all supernatural beings. The Winchester family sets out to retrieve the gun from the vampires so they can use it to kill the demon that took Sam and Dean's mother.
Meg turns to killing John's friends in order to get the Colt. Sam and Dean stakeout the Demon's next target; a family with a six month old baby showing signs of special abilities. John heads off alone to confront Meg.
Sam and Dean listen to a message on John's cell phone from a woman named Ellen (guest star Samantha Ferris)and decide to track her down. They are shocked to discover Ellen runs a road house that also serves as a gathering place for hunters like themselves. Meanwhile, at a small town carnival, a demonic clown is persuading children to let it into their home so he can murder their parents.
The Winchester brothers enjoy Dean's new baby: a shiny newly restored car, while checking out a report of two recent human deaths and over a dozen split-open cows in the small town of Red Lodge, Montana. The local sheriff laughs at Sam and Dean's idea that a cult is behind it, claiming it happens naturally in the sun. But when Sam and Dean sneak into the morgue under false pretenses, they find a victim that has retractable vampire fangs. They catch demon hunter Gordon Walker, who claims to be a friend of their late father and having made both kills after six months of vampire chasing started years before to avenge his sister who was killed by a vampire. Dean confesses to him he misses his seemingly unstoppable dad desperately. The boys are just in time to save Gordon from another vampire, but Ellen Harvelle warns Sam that Gordon is capable, but too dangerous to work with. Returning to the motel, Sam is knocked down and kidnapped by the vampires led by Eli and Lenore, who claim their kind feeds on only cows. Being released unharmed, Sam believes them, but feels Dean's fist for forsaking their mission and suggesting Dean joins Gordon as a poor substitute for father. Then Gordon goes after the nest alone, anyway...
Dean and Sam assist Neil Levine, a heartbroken college kid who consoles his long-time crush after her breakup and then loses her in a car accident. Determined to have his feelings returned, Neil uses necromancy to bring her back from the dead. His efforts backfire when she returns as an angry and vengeful Zombie, forcing the brothers to stop her after she kills her boyfriend Matt and the girl he cheated on her with.
Visions show Sam, still hunting for the master demon with Dean, the way to another small town where paranormal events occur, some innocent, some chillingly evil. The Winchester brothers are convinced it's all the paranormal work of 23-year-old Andy Gallagher, but doubt as that boy, although a bit of an outcast loser living in a van filled with philosophy as well as rock music seems sincerely surprised and using his powers with self-control. Soon they find after rescuing Tracy from what seems his work there is another at least as able and less scrupled, in fact, Andy's secret twin-brother, whose vengeance for their separation strikes out mercilessly, a cool killer, which even Andy may be unable to help the brothers stop in his sadistic steps...
Another one of Sam's visions in which Dean kills a man by name of Duane Tanner sends the Winchesters to Rivergrove, a near ghost town facing mass demonic possession. Sam and Dean begin to believe that the demons are trying to destroy the town from the inside out when the remaining town-folk try to kill them.
Sam is shocked when Dean finally tells him their dad asked him to watch over Sam to save him, or if that fails kill him. Sam leaves alone to let Ash look up a same-type clairvoyant demonic victim. Ava Wilson, from Peoria, Indiana, fits that bill and looks up Sam to warn she saw his death, then leaves ridiculing him. Dean followed Sam, just in time to intervene when crazy Gordon Walker turns up, who will stop at nothing to destroy 'utterly evil' Sam. It's a testing fight for the brothers.
Sam and Dean visit the Pierpont Inn, a creepy old mansion turned failing hotel. They meet the owner, Susan, and her daughter Tyler, who are packing to move after they sell the hotel. Tyler is playing with a little girl named Maggie. The brothers notice strange items around the hotel, including an urn with a familiar pattern, dolls with their heads backwards and Susan's mother, who looks vacant and beyond terrified. When Susan finds them in her mother's room trying to talk to her, she throws them out and threatens to call the cops.
A jewelry store heist committed by an employee and linked to a mysterious bank robbery bring Sam and Dean into the chase. The weird part seems to be the fact that the suspects commit suicide directly following the heist. A friendly tip points towards another shapeshifter. However, the search is interrupted by a hostage crisis.
In Providence, Rhode Island, the local Gloria kills a man claiming that an angel in a beautiful white light had chosen her for redemption and asked her to stab the sinner to accomplish God's will. Dean and Sam investigate the case and they discover that other people had been visited by the angel and committed murders. Further, the angel has appeared after the death of Father Gregory, who was murdered on the steps of his church two months ago. When Sam is visited by the angel and asked to kill a man, the skeptical and atheist Dean confronts the faith of Sam telling that men cannot be angels and the light is an angry spirit indeed.
After Sam goes missing for over a week, Dean finally receives a phone call from his brother. Dean finds Sam in a hotel room, covered in blood and suffering from the effects of a week long memory blackout. Upon investigation, the brothers find a video-tape of Sam killing another hunter in cold blood, which leads Sam to believe his dark side is taking over. When the dark side finally emerges Sam attacks Dean and continues on his hunter killing spree with his next targets being family friends Jo Harvelle and Bobby Singer.
When colleague hunter Bobby Singer arrives, the Winchester brothers tell him alternative versions, each incriminating the other, of their weird experiences in a university where improbable stories happened. Professor Cox made a fatal fall when seduced by a non-student girl, a frat's pledge-master reportedly suffered extreme hazing after an alien abduction, a research assistant's arm was eaten alive by a sewer alligator. Sam lost his computer, Dean his car. Bobby concludes it's the work of a trickster demon. The brothers have a single suspect, who puts on a grand final fight of wit and temptation.
Molly and her husband are driving along a long deserted highway at night when they come upon a farmer in the middle of the road who Molly tries unsuccessfully to not hit. Next thing she knows her husband is missing and the farmer is chasing her. Things get worse when the Winchesters inform Molly that the farmer is actually a highway ghost who, it seems, appears annually to get his revenge on her.
The Winchesters go undercover as production assistants (PAs) on a haunted movie set after getting wind of reports of tag teaming ghosts. The brothers deal with an asinine studio executive out to make cheap marketing stunts(guest star Gary Cole), a disenfranchised screenwriter seeking revenge for unnecessary revisions to a formally great script, and Dean's fan-boyish feelings for the leading lady.
When an old block is reopened in the Green River County Detention Center after thirty years, a fiend is released, killing the inmates. Three months later, Dean and Sam are arrested during a heist to be sent to the haunted prison to help Deacon, a former friend of their father. While FBI Agent Victor Henricksen presses Dean, the public defender Mara Daniels believes the brothers are not guilty of most of the inconsistent charges against them, and helps the Winchester brothers in the end.
Dean gets attacked by a Djinn, a creature capable of warping reality. The next things he knows he's in Lawrence, Kansas, in a stable relationship with a woman named Carmen, his mother is alive and well, and he and Sam are no longer on speaking terms. When the idea of a peaceful existence begins to settle in, visions of his previous life as a hunter start appearing out of nowhere.
The Yellow Eyed Demon transports Sam, Andy, and Ava along with other "Special Children" Jake and Lily to the remains of a ghost town to initiate the first steps of his war against mankind. Dean contacts Bobby Singer, Ash, and Ellen for help in locating his brother.
Sam, Dean, and Bobby deal with the ramifications of the Gate to Hell opening, meeting the demon incarnations of the Seven Deadly Sins, while Dean is living life to the fullest in the shadow of a deal he made with the Crossroads Demon, and a mysterious blonde woman with a demon-killing knife assists Sam.
A strange death reported in the newspaper prompts Dean and Sam to find Lisa Braeden, a woman Dean had a weekend fling with about 8.75 years ago, only to find she has a son turning 8. While investigating the death in the paper along with several other mysterious recent deaths, Sam and Dean find they are chasing a Changeling, who is replacing children with it's offspring. The mysterious blond woman is back, giving Sam a cryptic message that he should look into his mother's friends.
The Winchesters are called regarding a robbery of their father's storage unit, and track down the robbers to find the item stolen is a cursed rabbit's foot, which provides great luck until lost, and once lost the previous owner dies within a week. Sam picks up the foot and has great fortune, until it is pickpocketted away by the mercenary Bela. Dean must then get it back before Sam's bad luck gets him killed. To complicate the whole situation, Gordon, from his prison home, has convinced two other hunters that Sam is pure evil and must be killed.
The Winchester boys head to Ohio to research several deaths in a small town, where sin has taken a firm foothold on the population; prostitution, adultery, alcohol abuse, murder, and suicide are all prevalent in the once quiet town. Dean has a revealing conversation with a demon possessed woman. The demon Ruby assists Bobby in restoring the Colt to it's demon-killing grandeur.
The 'Three Little Pigs' and 'Hansel and Gretel' come to life and attract Sam and Dean's attention to Maple Springs, NY, where they try to prevent 'Little Red Riding Hood', 'Cinderella', and 'Snow White' from having unhappy endings. Sam also confronts the Crossroad Demon with the newly refurbished Colt.
Strange land-locked drownings are happening and the boys head to the coast to find out why, discovering a Ghost Ship has been witnessed by each of the victims shortly before their deaths. They find that Bela is already involved, running a scam on elderly Gertrude Case, the aunt of the first victim with a crush on Sam.
Gordon Walker is out of prison and out for blood, Sam's blood, and pays Bela to reveal their location. Meanwhile, the Winchesters are hot on the trail of a vampire named Dixon, who in turn has a beef with Gordon.
Sam and Dean follow the trail of an Anti-Claus when victims are apparently pulled up the chimney never to be seen again. After a lead goes nowhere, the Winchesters learn the Anti-Claus in in fact a pair of old pagan gods who have assimilated into society and have found a new way of getting their yearly sacrifices. A flashback to Christmas Eve 1991 reveals how Sam found out for the first time what their father really did and where Dean got his gold amulet.
The Winchesters encounter the mysterious and very much still alive Doc Benton when they look into a series of abductions where the victims report missing body parts after forced surgery. When Bobby manages to locate Bela, Dean heads off to confront her and get the Colt back. Meanwhile Sam stays behind hoping that Doc Benton can make Dean immortal to get him out of the Deal.
Dean's time is up and he has to pay the Devil his due. When Lilith resurfaces in New Harmony, Indiana terrorizing a family to no end Sam, Dean, and Bobby steal Ruby's knife and confront the mother of all demons in a battle to the death.
Sam tries to move on without his brother and becomes hardened and more reckless in the way he hunts. Bobby and his psychic friend Pamela try to contact the other side to find out more about Dean's ultimate fate.
Castiel sends Dean back in time to 1973 where he encounters younger versions of his parents and for the first time meets his grandfather Samuel Campbell who holds a secret that sheds a light on the Winchester Family's connection to the hunter community.
A hunter named Travis points Sam and Dean towards a meat eating creature called a Rugaru. Complicating matters is the fact that Travis's target is a normal suburban dad in the earlier process of changing and he hasn't killed anyone yet.
Sam and Dean discover a Colorado small town's darkest secret as a wave of people fall prey to a "ghost sickness" that induces fear, paranoia, and ultimately a fatal heart attack. Sam and Bobby must figure out the cause and cure of the sickness when Dean himself falls prey to it.
Sam, Dean, and Ruby discover the existence of a female prophet named Anna Milton, who can hear the voices of angels and thus figures into the plans of a demon named Alastair who wants to use her as a tool against the angels.
Dean and Sam figure out why Castiel and Uriel want Anna Milton dead when the three of them are forced to go on the run, not only from heavenly and vengeful angels, but from Alastair and his demon minions who also try to track down Sam, Dean, and Anna. With the assistance from the now-blind soothsayer, Pamela Barnes, they discover that 'Anna' is a fallen (former) angel and needs to seek her grace wings before the forces of both Heaven and Hell find them.
In an alternate reality mysteriously created as if Sam and Dean were never brothers and have never met, Sam and Dean work at a marketing office where they are forced to team up with one another when a series of mysterious suicides point to a ghost haunting the premises.
Sam and Dean are contacted by one Adam Milligan who claims to be John Winchester's son. The boys immediately suspect a demon trap and go to investigate. Adam turns out to legitimately be John's son and Dean is furious that John kept Adam's existence from them as well as sheltered Adam from the hunting life. Meanwhile other supernatural forces are at work, which lead to a tragic twist that neither Sam, Dean, or their new sibling could have guessed.
Castiel has been sent back to Heaven. His human host, Jimmy, tries to regain his life. But the demons won't leave him alone and now his family is at risk. Sam and Dean can help a little, but they're going to need a "miracle" to win.
Sam is becoming more and more inhuman. Dean and Bobby put him in the safe hold until he gets over his addictions. After Sam escapes with help, unknown to him, from Castiel, he finds Ruby and begins to feed once again. Dean begins to truly believe that the old Sam is gone for good.
When the last few of the 66 Seals are broken by Lilith's minions, Sam and Dean prepare for the big and probably futile fight in very different ways. Sam joins Ruby on a final attempt to kill Lilith before Lucifer rises, while Castiel and Zachariah tell Dean that it's time to play his part in stopping Lucifer.
In the aftermath of the Devil rising, Sam and Dean are whisked away and they are given a message from Chuck Shurley that Castiel is dead and that Lucifer walks the Earth. As a result, Sam and Dean turn to Bobby for help to find a mystical weapon, called Michael's Sword. This will enable them to find the Devil before he takes on a new form to bring the slow end of the world. But the Winchester brothers are pitted against the archangel Zachariah who has plans for Dean, as well as more demons. Sam and Dean recognise a demon, Meg, who has returned from Hell.
Not sure he trusts himself, Sam decides to give up hunting and goes off on his own. But that night, a late-night visitor tells Sam that he won't let him off the hook that easily. Dean, intent on stopping the Apocalypse, continues hunting on his own and teams up with Castiel to find the Archangel Raphael since Castiel believes Raphael knows the location of God's vessel on Earth.
Dean awakens five years in the future in an abandoned city and is attacked by humans infected with a demonic virus that makes them mindless, flesh-eating zombies. Zachariah soon appears and explains to Dean that the world he sees is the result of his refusal to help the angels fight Lucifer.
Sam and Dean decide to start hunting together again and their first case leads them to a small town whose inhabitants are being killed by famous dead icons like Abraham Lincoln and James Dean, etc. Once they discover Paris Hilton has been involved in demonic crimes too, they don't know what to believe anymore.
Sam and Dean investigate a series of odd murders that strangely resemble fairy tales and urban legends. The brothers track down an 11-year-old boy named Jesse, and realize that whatever Jesse believes is coming true. Castiel appears again and tells Sam and Dean that Jesse is a serious threat and needs to be eliminated which deeply disturbs and divides them since it is against the Winchester brothers' custom of killing a human.
Sam and Dean discover that a witch is running a high-stakes poker game where the currency is life years vs. money. Bobby sees the game as a chance to get out of the wheelchair and bets 25 years, but loses. As Bobby begins to age rapidly, Dean steps in to save him but also ends up turning into an old man, leaving Sam holding the only hopes for their survival.
Sam and Dean catch up with the Trickster, who sends them through a dizzying montage of TV show parodies, inviting them to play along with their "roles" or be stuck in "TV Land" forever. But once Castiel shows up, the boys get an idea as to what the Trickster might be hiding and eventually come up with a surprising answer.
Dean and Sam are at a Supernatural convention where they meet lots of fans of the Supernatural Books. After a while they get the impression that something is not right at the location of the convention.
When a former hunter calls Sam and Dean for help from inside a mental institution, the brothers get themselves admitted as patients to check out his claims of supernatural phenomena. When their incarceration pushes them both to the breaking point their personal issues send them over the edge.
In Massachusetts, seventeen year-old nerd Gary uses witchcraft to swap bodies with Sam. Gary has lots of fun with the sexy Crystal and following Dean, who is hunting the witch Maggie Briggs. Meanwhile, Sam is trapped in the body of the teenager and trying to find out how Gary had succeeded in the black magic, and also trying to communicate with Dean. When Sam meets Gary's friends Trevor and Nora, he discovers that the intention of the teenagers that are playing a deadly game with the witchcraft.
The renegade angel Anna escapes from her prison in heaven. She travels back in time to kill Sam and Dean's parents so that Sam is never born, and cannot be the vessel for Lucifer. Castiel sends Sam and Dean back to stop Anna.
A couple of days before Valentines Day, two valentines devour each other. On the next day, two lovers commit suicide. Dean and Sam investigate the murders and summon Castiel to help them. Castiel tells that the responsible is a cupid that has gone nuts. The angel brings the cupid and they conclude that he is innocent. When Sam feels hunger for demon blood, they discover that the local population has been attacked by Famine, one of the Four Horsemen of the Apocalypse.
Sam and Dean investigate Bobby's home town where the dead are rising from the grave but instead of attacking humans, they are happily reuniting with their families. The brothers turn to Bobby for help but he tells them not to worry about it and to leave town. Suspicious, Dean investigates and comes face to face with Bobby's dead wife who has no memory of what happened to her. Once the zombies start turning evil, the boys tell Bobby he has to kill his wife but he refuses.
Dean and Sam are killed by the hunters Walt and Roy. They awake in heaven and Castiel contacts Dean and asks him to seek out the angel Joshua. Meanwhile Zachariah is chasing them in Heaven to force Dean to be Michael's vessel.
Dean has decided to say yes to Zachariah and Michael to stop Lucifer and avoid the Apocalypse. However, Castiel brings their half-brother Adam, who is the Plan B for the angels. Zachariah lures Adam about the feelings of the Winchester brothers, forcing Dean, Sam and Castiel to fight against several angels to rescue Adam.
Dean and Sam, in the midst of a long drive, stop for the night in a remote four-star hotel. Soon they learn that Kali, Baldur, Odin and other pagan gods have kidnapped the guests to eat them. Dean and Sam realize they are also trapped and being used as bargaining chips in an effort to stop the Apocalypse. Out of the blue, Gabriel arrives to warn Kali and the other gods that Lucifer will destroy them; however, it is too late since Lucifer has just arrived in the hotel.
Dean and Sam are heading east in their Impala tracking down a swine flu outbreak. Out of the blue, the cunning demon Crowley appears in their car and offers to help them to find the last two Horsemen to get their rings. Crowley explains to the reluctant brothers that he wants Lucifer trapped and he knows a demon that can tell the location of Pestilence. Dean heads with Crowley to the Niveus Pharmaceuticals, and they abduct the demon Brady, who had studied with Sam and was his friend. Crowley unsuccessfully interrogates Brady; however, when they hear a hell hound howling, the demon Brady changes his attitude and gives the location of the Pestilence.
Dean has an argument with Sam that wants to say "yes" to Lucifer to trap him. However, they go to the Serenity Valley Convalescent Home where Pestilence is and they are defeated by the Horseman. Out of the blue, Castiel appears and gets his ring. Bobby sells his soul to Crowley to get the information of where Death is. Crowley recovers Bobby and makes him walk. Dean, Sam, Bobby, Castiel and Crowley head to Chicago to meet Death. Bobby, Castiel and Sam find that Niveus Pharmaceuticals will supply vaccines with the Croaton virus. When Dean sees Death in a pizzeria, the Horseman surprisingly proposes a deal to Dean; in return, he gives his ring to Dean.
One year ago, Dean moved to Lisa's house to live a normal, "apple-pie" life with Lisa and her son Ben, as recommended by Sam, working as a construction worker. One day, Dean finds scratches of Djinn in several places and he chases the supernatural being. When his is attacked by the Djinn, he is saved by Sam that tells him that he was released from hell one year ago and teamed-up with their Grandfather Samuel and three Campbells. Now Dean has to decide whether he wishes to leave Lisa and Ben to hunt demons again or stay with his regular life.
When four families are killed and their babies are missing, Sam finds that a security company may be involved in the case and summons Dean to help him to bring the baby of a fifth slaughtered family to Samuel. However they are chased by a powerful shape shifter that wants the baby and they discover that the baby is a new breed.
Sam calls Dean and asks him to head to Easter, Pennsylvania, to investigate the mysterious and gory death of two police officers. They visit the police officer Toby Grey that had witnessed the death of his partner and they learn that the three police officers had killed a teenager and planted a gun to justify their action. Then Toby dies in front of the Winchester brothers. They summon Castiel and they learn that the police officers were killed by Moses' staff. Further, Castiel tells that Heaven is chaotic and several lethal weapons have been stolen. They visit the family of the deceased teenager and they discover that his little brother has sold his soul to an angel; in return, he received part of the staff that he used to kill the officers. Further Castiel discovers the identity of the person responsible for the tragedy.
Bobby summons Crowley and finds that the demon has no intention of returning his soul and has given ten additional years of life for him. Meanwhile, Dean and Sam ask Bobby to advise which demon is killing people in Wisconsin, and after a long research, Bobby informs that is a Lamia. Then Rufus knocks on Bobby's door with the corpse of a demon Okami to bury it. However the demon is still alive and Bobby has to seek it out and vanquish the demon. Dean and Sam travel to Scotland and help Bobby to get his soul back. When Bobby is ready to eat a slice of the peach cobbler his next door neighbor Marcy Ward gave to welcome him in the neighborhood, he receives another urgent phone call.
When six teenage girls disappear in seven days in a small town, Dean and Sam investigate the case. They go to the house of the last girl that went missing, Kristen, and they find that the girl is a vampire fan. Sam hacks her notebook and finds that Kristen had a date with a weird guy in the Black Rose bar. The Winchester brothers go to the place and they discover that there are many vampires there. While fighting with a strong vampire, he forces Dean to drink his blood and Dean is turned into a vampire. Samuel tells that the only chance that Dean may have to become human again is killing the vampire and using his blood to revert the transformation.
After four suspicious suicides, Dean and Sam investigate the cases and they discover that the suicidal victims have heard painful truths before their final act. Their further investigation shows another death that might have been suicide. They visit the victim's sister and they discover that she had invoked Veritas, the Goddess of Truth, who feeds of the victims of the truth. Soon Dean becomes her next victim and he uses his fate to question Sam about what has happened after his return from Hell. But when Veritas captures the Winchester brothers, they hear truths about each other.
Dean becomes suspicious of Samuel's motives, but Sam isn't sold on the idea that their grandfather is doing anything wrong. The brothers go along on a hunt with Samuel and the other Campbells, but things go terribly awry.
Crowley bosses Dean and Sam and sends them to Buffalo, New York, to capture an Alpha werewolf that is killing people. Crowley would return Sam's soul if they succeed and bring the Alpha to him. Soon they discover that the killer is actually a skinwalker posing as the family dog Lucky that loves his owners Mandy and her son. He kills those that threaten the family to protect them. Dean and Sam catch Lucky and they discover that there are thirty skinwalkers living as family dogs and ready to transform their families into an army of skinwalkers. Now Dean and Sam want to destroy the pack and the Alpha.
When a fourth person vanishes in Elwood, Indiana, and the witnesses claim that they have been abducted by aliens, Dean and Sam head to the town to investigate the UFO sightings. They contact the father of the last victim, Mr. Brennan, who is a traditional watchmaker, and the Winchester brothers suspect that the man is hiding something. Dean and Sam interview people on the streets expecting to find a clue. Among the interviewees, they talk to UFO expert Wayne Whittaker Jr. and the apparently crazy Marion, who is an expert in fairies. While investigating the cornfield where the victims had disappeared, Dean is abducted by a bright light. Sam continues to investigate and forces Brennan to disclose that he had used a spell to summon fairies to help him in his store. Dean returns and now the only chance of the brothers is are the advices of Marion about the fairies.
Dean and Sam are captured by Meg who wants to know Crowley's hideout. Sam proposes to show where Crowley is provided she gets his soul back. The Winchester brothers ask the reluctant Samuel who has made a deal with Crowley to have his daughter Mary back but he finally points out the spot. Dean and Sam break into an old prison with Castiel, Meg and two other demons to seek out Crowley, but they are betrayed by Samuel. Castiel escapes, but Sam and Dean are arrested and Meg is tortured by Christian. Will that be the end of the quest of the Winchester brothers for Sam's soul?
Dean goes to Dr. Robert to have a 3 minutes near-death experience to meet Death. They have a meeting and Death proposes Dean wear his ring for 24 hours; in return, Death would retrieve Sam's soul, return it to Sam's body and put up a wall to isolate his traumatic period in Hell. Dean becomes Death for a day with the guidance of Tessa and soon he learns that the natural order cannot be violated. Meanwhile Sam summons Balthazar to help him find away to keep his soul from being put back, but he must kill Bobby to do it.
Dean and Bobby investigate the disappearance of teenage girls when Sam awakes after recovering his mended soul. Bobby still does not trust Sam and Dean and his brother travel to investigate further. They find that the abducted girls are virgins and that dragons are the responsible for the kidnappings. Dean calls Bobby and he tells the name of a specialist that may teach them how to vanquish the dragon. While Sam searches where the dragon might be hidden, Dean visits Dr. Eleanor Visyak that tells him that he needs a blade forged with dragon blood. Dean borrows a piece of the weapon with her and he goes with Sam to the sewage system where they find the missing girls. They also recovers a Fourteen Century paper and Bobby translates parts and discovers that the dragon wishes to open the purgatory's door to release the Mother of all.
Sam receives a text about the disappearance of four young women and together with Dean, they head to Bristol, Rhode Island, to investigate the case. Sam has flashbacks with recollections from the town and he partially remembers that he had been in the spot one year ago to investigate missing men, and he believes that the cases are connected. The mystery increases when Dean discovers that Sam had had love affairs with the missing girls. When Sam meets the widow Brenna Dobbs, whose husband Sheriff Roy Dobbs had also disappeared, he finally recalls Arachne's case and what has happened to Roy.
Dean and Sam travel to New Jersey to investigate a mysterious murder cases. However, Ben calls Dean and tells that it is an emergency situation and he heads to Lisa's house, leaving Sam alone. Sam discovers that the victims had played a prank on their colleague Rose and their deaths might have been caused by her revengeful ghost. Meanwhile Dean also learns what the "emergency situation" reported by Ben is about.
After a series of brutal murders, Dean, Sam and Bobby travel to investigate and they meet Rufus. They team-up and find that Eve, a.k.a. The Mother of All, is the responsible for the killings. When they find a clue of the location where she might be, they stumble upon Samuel and Gwen who are also chasing Eve. Soon they learn that Eve has created an evil worm that penetrates through the ear and force the victim to kill. Now they do not know who might have been possessed by the creature.
After a series of weird deaths in Chester, Pennsylvania, Dean and Sam discover that Balthazar has changed the history, avoiding the collision of the Titanic with an iceberg. Now Fate is intervening, murdering the descendants of those that should have died. The dilemma for the Winchester brothers is that Ellen and Jo are alive and if Castiel restores the time line, Ellen and Jo will be gone. Further, Castiel advises Dean and Sam that Fate is angry with them and they need to kill her to survive.
Lenore tells to Dean, Sam, Bobby and Castiel that Eve is in a small town in Oregon and they head to hunt her down. Soon they discover that the locals have been transformed in hybrid species of demons and Dean calls them "Jefferson Starships". When they meet the Mother of All, they discover a secret about Crowley.
Bobby tells Dean and Sam that Castiel has stolen the Moishe Campbell Diary, but he has a copy. They read the journal and discover that in 1937, H.P. Lovecraft had opened a gate to Purgatory with five worshipers of the devil. Meanwhile Crowley abducts Lisa and Ben to force Dean and Sam to step back. Sam summons Balthazar for help and the angel is surprised by the revelations of the partnership of Castiel with Crowley. While the boys seek out Lisa and Ben, Bobby investigates what happened on 10 March 1937 and discovers the truth about his friend Ellie. Balthazar brings the brothers to an angel-proofed warehouse where Lisa and Ben are held captive. When Dean reaches them, he discovers that Lisa is possessed by a demon.
The wall comes down in Sam's head and all hell breaks loose. Dean and Bobby are, for once, at a total loss on how to help him and are forced to stand by and do nothing while Sam breaks. The battle for heaven comes to a head.
Sam and Dean investigate the murders of mediums in Lily Dale, the most "psychic" town in America. They discover that an angry spirit is killing off the psychics, but in a town full of people who claim to be summoning spirits, they have a little trouble identifying the medium controlling the ghost.
Sam and Dean discover that Frank's hard drive, containing everything on the leviathans, is now in Dick's company building. To retrieve it, they ask for help from one of the employees, a young computer hacker.
Dean returns from Purgatory, one year after the fight with the Leviathans. After reuniting with Sam, they find out that Kevin escaped Crowley with another Word of God that may hold the key to closing the gates of Hell forever.
Castiel decides to become a hunter, like Sam and Dean. But his first day on the job is a doozy when they investigate a series of murders caused by old cartoon gags. Meanwhile, Sam thinks back to his first time meeting Amelia's father.
Sheriff Mills calls Sam and Dean for help with multiple disappearances in the town. Discovering all four victims belonged to the same church chastity group, Sam and Dean decide to infiltrate by joining the group themselves.
Charlie returns from Oz - Sam is scanning the internet for suspicious paranormal activity and comes across a video of Charlie beating up a district attorney. Dean suspects she's back from Oz and hunting on her own, assuming the district attorney must have been a demon. When they do find Charlie, they are shocked when she tells them why she really came back from Oz.
Despite Dean's directive to forget about looking for a cure for the MOC, Sam continues to do research. Dean suspects Sam is hiding something but decides to focus on a murder case where they run into Cole.
While investigating a strange murder, Sam and Dean discover the killer has the same tattoo as those from the Styne family; Castiel plays referee when Charlie and Rowena must work together; Crowley turns to an old enemy for help with Rowena.
Sam and Dean try to help Castiel recover from Rowena's spell, while searching for Amara who has now grown into a young girl. Rowena tries to use her powers to protect herself from the Winchesters, while Crowley tries to use Amara for his personal gain.
Sam and Dean investigate a series of murders at a local B&B that also happens to be Lizzie Borden's old home. When a man tells them he saw a little girl around the B&B around the time of the murders, the brothers realize Amara may be responsible.
Castiel seeks out Metatron's help to stop the Darkness. However, Metatron is pretty happy with his new life as a freelance videographer for the local news and isn't inclined to help the Winchesters or Castiel.
Claire believes recent murders in town are supernatural and asks Sam and Dean to investigate. However, Sheriff Mills tells the guys that Claire has been getting into trouble lately and has been attacking normal people and accusing them of being monsters.
After dangerous creature is released into an old house, a mother and child are comatose. Sam and Dean find that Bobby and Rufus tracked the same creature so the Winchesters look to the past to catch the monster before any one dies.
Sam and Dean are visiting a small town in Colorado where people are mysteriously disappearing every 27 years. While they are investigating, the boys encounter a pair of hunters seeking revenge on the monster causing the disappearances.
Dean, Castiel and Mary have a lead on Sam and set out to rescue him. Dean is uncomfortable putting Mary in danger, but she insists on going. Meanwhile, Crowley is tipped off that Lucifer has taken over the body of rock star Vince Vicente.
Sam and Dean investigate a case that leads them to a devout religious family living off the grid. They realize the parents are hiding a huge secret that could destroy them all. Meanwhile, Dean struggles to accept Mary's latest decision.
Lucifer realizes that as Vince Vincente, he can get his fans to do whatever he wants. Thrilled with this power, he arranges a VIP concert in order to kill them. Sam, Dean and Castiel enter the underbelly of the music industry to stop him.
After being arrested for the attempted assassination of the POTUS Sam and Dean must find a way out of a government detention facility in the middle of nowhere. Determined to find her sons, Mary and Castiel seek help from an unlikely source.
Sam and Dean investigate an attack by an invisible hellhound at a campsite. Meanwhile, two of Crowley's own personal demons uncover what he has been hiding. Elsewhere, Castiel gets a lead on Kelly Kline.
Dean and Sam let Mick Davies tag along on a case as they search for a werewolf and they run into Claire Novak, the reunion is short lived after Claire is bitten and the brothers race to find a way to help her before she turns.
Alicia Banes calls Mary for help after her mother, Tasha goes missing. Sam answers Mary's phone and he and Dean head out to help Alicia and her twin brother, Max find their mother who was hunting a powerful witch. Meanwhile Mary starts to have some doubts about the British Men of Letters.
Sam and Dean are alarmed when they learn hunters are being killed by suspicious "accidents" all over the country. They decide it is best to find Mary and make sure she's safe. Meanwhile, Toni is back in the states and she and Mary face off.
A wraith kills her friend and Missouri enlists the help of Dean and Jody to protect her granddaughter, Patience, and could be next on the wraith's hit list. Sam continues to work with Jack to control his powers.
When multiple patients of grief counselor Mia Vallens turn up dead, Dean, Sam and Jack investigate the mystery surrounding the murders and, each inadvertently, are forced to deal with unresolved grief of their own.
Castiel is reunited with Jack and together with Sam and Dean, they head to a sleepy old western town to investigate a murder. Dean gets to live out his boyhood fantasy when he comes face to face with a famous, gun-slinging outlaw.
Jack, desperate to prove to Sam and Dean that he is good and that he can control his powers, enlists the help of a dream walker named Kaia to help him find Mary Winchester and save her from the alternate universe. However, when plans go awry, the Winchester brothers are the ones who need saving.
When Dean and Sam go missing Jody Mills calls Claire Novak and tells her to come home they need to find the Winchesters. As they search for Kaia the dreamcatcher who opened the rift Jody is worried about Patience's vision.
Dean falls victim to a couple of witches, sisters Jamie and Jennie Plum who manage to steal a powerful book of spells from the Winchesters. When Dean and Sam go after the book, they get help from a powerful and surprising ally when Rowena, back from the dead, intervenes to assist them.
Jack and Mary escape Michael's clutches and end up finding an ally in Bobby Singer; Sam, Dean, and Castiel continue to search for a way to open a breach; one of their own may be working against them and costing them precious time.
Sam and Dean are close to collecting everything they need to open a rift into the Apocalyptic World and possibly rescuing Mary (guest star Samantha Smith) and Jack. The one missing ingredient leads the Winchesters to a black market for religious relics where everything is not always as it seems.
Sam and Dean continue to collect the pieces necessary to open a rift to the other world in order to save their family. Their latest quest leads them to a Men of Letters bunker from the 1920s and a hungry God from another dimension. Meanwhile, Ketch makes a shocking decision about Gabriel after an unruly encounter with Asmodeus.
Lucifer rules over heaven but things aren't going exactly as planned, exasperating his first lady, Jo. Sam and Castiel are perplexed by the return of Gabriel. Meanwhile, Dean gets one step closer to finding Mary and Jack.
Gabriel is back and drags Dean and Sam into his plot for revenge on the demigods who sold him to Asmodeus. Meanwhile, Jack's growing confidence leads to reckless decisions that could put others in harm's way.
Sam, Dean, Castiel and Gabriel must work together if they have any hope of bringing Mary and Jack home. Meanwhile, Rowena's encounter with Lucifer may alter the outcome of the journey for one of our heroes.
Sam enlists everyone's help in trying to track down Dean, who can literally be anywhere. Meanwhile, Castiel may be in over his head after meeting up with an unreliable source. After being drained of his grace, Jack is adjusting to life as a human, learning new skills and figuring out how he fits in to this world of hunters.
Still trying to solve the mystery of what happened to Dean, Sam enlists the help of Sheriff Jody Mills who may unknowingly already be on the case. Castiel continues to be a father figure to Jack, who surprises even himself, when a life is on the line.
Sam and Castiel track down a Shaman who may be able to help a friend. Nick continues to spiral down a dark path as he looks for answers surrounding the deaths of his wife and son. Jack turns to Dean for help enjoying the human experience.
When Dean and Sam join forces with an unexpected ally, the outcome will alter the course of two lives. Meanwhile, Heaven faces an attack from a dark force, driving Castiel to make an enormous sacrifice to make things right.
Sam and Dean enlist the help of their pal Garth to gain inside information on what Michael may be planning. The brothers split up to each go after weapons that can aid in their fight against the Archangel, but this may be a fight our heroes cannot win.