Night at the Museum screenwriters Thomas Lennon and R Ben Garant are behind the new movie, which will be released by Paramount.
News of the Naked Gun reboot was broken by Variety.
Leslie Nielsen originally played the Drebin character in the short-lived TV series Police Squad!, and the character made the leap to the big screen in the 1988 movie The Naked Gun: From the Files of Police Squad!
Video: Watch a classic scene from 'The Naked Gun'
Two sequels - The Naked Gun 2½: The Smell of Fear and Naked Gun 33⅓: The Final Insult - followed and the series made $350 million at the worldwide box office.
Helms is best known for playing The Office's Andy Bernard and Stu from The Hangover trilogy.
The actor recently starred in We're the Millers and