The team are bewildered by a recent shocking revelation as they face a difficult decision. Meanwhile, Bobbi and Mack declare their loyalty to Hunter; and Ward and Agent 33 take care of a private matter.
War comes to Coulson's doorstep in a way he never anticipated as shocking revelations are brought to light, and Skye struggles to control her new abilities but will soon make a decision that irrevocably changes her life.
As Robert Gonzalez makes his move, Coulson must do whatever it takes to protect the future of S.H.I.E.L.D. Meanwhile Skye's journey to control her powers take a surprising turn when she meets the enigmatic Inhuman named Lincoln.
The story of Melinda May's transformation into "The Cavalry" is revealed as she finds herself at a crossroads in the war between Coulson and Gonzales. As Skye learns more about her true heritage from Lincoln, the truth about Inhumans will send her in a new direction.
A dangerous new alliance is formed as Coulson and Hunter turn to the last person anyone would expect, Grant Ward! As the war between S.H.I.E.L.D. factions continues, Skye and Lincoln will find themselves drawn into this conflict.
S.H.I.E.L.D puts everything on the line to survive a war that blurs the line between friend and foe. Coulson and his team will be forced to make shocking sacrifices that will leave their relationships and their world changed forever.
Director Phil Coulson and Agent Daisy Johnson leading the charge as S.H.I.E.L.D. searches the world for more powered people in the aftermath of their epic battle with Jiaying and her army of Inhumans. However, Coulson and the team soon find out that they are not the only group looking for these new Inhumans.
Having reluctantly agreed to share information with Rosalind and the ATCU, Coulson and the team search for the Inhuman who is killing other Inhumans; May feels that Hunter's mission to take down Ward is getting too personal.
As Daisy and the team try to protect Inhumans, a shocking truth is revealed about S.H.I.E.L.D.'s biggest enemy; with Fitz's help, Simmons recovers information that could get them back through the portal.